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As Hamilton County deals with record-breaking homelessness, advocates break down reasons and solutionsFortune Brands Innovations Inc. stock falls Thursday, underperforms market
None“Gladiator II” asks the question: Are you not moderately entertained for roughly 60% of this sequel? Truly, this is a movie dependent on managed expectations and a forgiving attitude toward its tendency to overserve. More of a thrash-and-burn schlock epic than the comparatively restrained 2000 “Gladiator,” also directed by Ridley Scott, the new one recycles a fair bit of the old one’s narrative cries for freedom while tossing in some digital sharks for the flooded Colosseum and a bout of deadly sea-battle theatrics. They really did flood the Colosseum in those days, though no historical evidence suggests shark deployment, real or digital. On the other hand (checks notes), “Gladiator II” is fiction. Screenwriter David Scarpa picks things up 16 years after “Gladiator,” which gave us the noble death of the noble warrior Maximus, shortly after slaying the ignoble emperor and returning Rome to the control of the Senate. Our new hero, Lucius (Paul Mescal), has fled Rome for Numidia, on the North African coast. The time is 200 A.D., and for the corrupt, party-time twins running the empire (Joseph Quinn and Fred Hechinger), that means invasion time. Pedro Pascal takes the role of Acacius, the deeply conflicted general, sick of war and tired of taking orders from a pair of depraved ferrets. The new film winds around the old one this way: Acacius is married to Lucilla (Connie Nielsen, in a welcome return), daughter of the now-deceased emperor Aurelius and the love of the late Maximus’s life. Enslaved and dragged to Rome to gladiate, the widower Lucius vows revenge on the general whose armies killed his wife. But there are things this angry young phenom must learn, about his ancestry and his destiny. It’s the movie’s worst-kept secret, but there’s a reason he keeps seeing footage of Russell Crowe from the first movie in his fever dreams. Battle follows battle, on the field, in the arena, in the nearest river, wherever, and usually with endless splurches of computer-generated blood. “Gladiator II” essentially bumper-cars its way through the mayhem, pausing for long periods of expository scheming about overthrowing the current regime. The prince of all fixers, a wily operative with interests in both managing gladiators and stocking munitions, goes by the name Macrinus. He’s played by Denzel Washington, who at one point makes a full meal out of pronouncing the word “politics” like it’s a poisoned fig. Also, if you want a masterclass in letting your robes do a lot of your acting for you, watch what Washington does here. He’s more fun than the movie but you can’t have everything. The movie tries everything, all right, and twice. Ridley Scott marshals the chaotic action sequences well enough, though he’s undercut by frenetic cutting rhythms, with that now-familiar, slightly sped-up visual acceleration in frequent use. (Claire Simpson and Sam Restivo are the editors.) Mescal acquits himself well in his first big-budget commercial walloper of an assignment, confined though he is to a narrower range of seething resentments than Crowe’s in the first film. I left thinking about two things: the word “politics” as savored/spit out by Washington, and the innate paradox of how Scott, whose best work over the decades has been wonderful, delivers spectacle. The director and his lavishly talented design team built all the rough-hewn sets with actual tangible materials the massive budget allowed. They took care to find the right locations in Morocco and Malta. Yet when combined in post-production with scads of medium-grade digital effects work in crowd scenes and the like, never mind the sharks, the movie’s a somewhat frustrating amalgam. With an uneven script on top of it, the visual texture of “Gladiator II” grows increasingly less enveloping and atmospherically persuasive, not more. But I hung there, for some of the acting, for some of the callbacks, and for the many individual moments, or single shots, that could only have come from Ridley Scott. And in the end, yes, you too may be moderately entertained. “Gladiator II” — 2.5 stars (out of 4) MPA rating: R (for strong bloody violence) Running time: 2:28 How to watch: Premieres in theaters Nov. 21. Michael Phillips is a Tribune critic.Microsoft's chief commercial officer sells $10.4 million in stock
Published 4:48 pm Wednesday, November 27, 2024 By Data Skrive Top 25 teams will take the court in three games on Thursday’s college basketball schedule. That includes the South Carolina Gamecocks taking on the Iowa State Cyclones at Suncoast Credit Union Arena. Watch women’s college basketball, other live sports and more on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Use our link to sign up for a free trial. Catch tons of live women’s college basketball , plus original programming, with ESPN+ or the Disney Bundle.No. 8 Kentucky flying high ahead of Western Kentucky meeting
NoneA local real estate group issued an apology after a group of attendees at its recent dinner and dance event were seen donning blackface make-up and Afro wigs. A photo of eight of the attendees posing in front of an event backdrop was posted on video-sharing platform TikTok on Nov 24. The clip had garnered more than 25,000 views as at 6.30pm on Nov 25, and the photo was later shared on social media platform X. Another photo posted on X shows them standing on stage during an event titled UOL & PPHG Annual Dinner & Dance x Remixed Party 2024. PPHG stands for Pan Pacific Hotels Group. In response to queries from The Straits Times, a UOL Group spokesperson said the company is aware of the incident. “We sincerely apologise for any offence caused,” the spokesperson added, without responding to questions about whether the attendees are UOL or PPHG employees and whether any action has been taken against them. Parent of Balestier Khalsa player apologises for racist remark A search by ST found that the event was held on Nov 14. Its theme was “The Rhythm of the Night”. Netizens criticised the attendees’ blackface make-up, with some saying they should be held accountable. In July, a Raffles Institution student wore a mask with the face of a dark-skinned man while posing as a food delivery rider on Racial Harmony Day. He was counselled and disciplined by the school after a photo of his inappropriate dressing went viral.Winners of 2024 St. Louis ORBIE Awards Announced By St.LouisCIO
ESTERO, Fla. (AP) — Al Green scored 19 points and Sean Newman Jr. added seven in the overtime as Louisiana Tech knocked off Southern Illinois 85-79 in a first-round contest at the Gulf Coast Showcase on Monday night. Green had three steals for the Bulldogs (5-0). Kaden Cooper scored 18 points and added 12 rebounds and four steals. Amaree Abram went 8 of 13 from the field to finish with 18 points, while adding six steals. Kennard Davis led the way for the Salukis (2-4) with 16 points, 10 rebounds and three steals. Southern Illinois also got 15 points and eight rebounds from Jarrett Hensley. Ali Abdou Dibba also had 12 points and two steals. Cooper scored 12 points in the first half and Louisiana Tech went into the break trailing 31-27. Abram's 16-point second half helped Louisiana Tech close out the six-point victory. NEXT UP These two teams both play Tuesday in the six-team, round-robin tournament. Louisiana Tech squares off against Richmond and Southern Illinois faces Eastern Kentucky. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Money Research Collective’s editorial team solely created this content. Opinions are their own, but compensation and in-depth research determine where and how companies may appear. Many featured companies advertise with us. . With AI models like ChatGPT, you can describe at length what you’re looking for — even if you don’t exactly know what that is yet. As we approach the holidays, artificial intelligence is taking center stage. Whether that’s a blessing or a curse — well, that depends on how the burgeoning technology is used. On one hand, Coca-Cola is facing fierce backlash after it used generative AI to reimagine its beloved 1995 “Holidays Are Coming” campaign. On the other, some proponents of AI say that the very same tool can reduce the stress of one of the biggest holiday to-dos: shopping for gifts. John Licato, a computer engineering associate professor and AI researcher at the , recommends using AI to help you pick the perfect gift for friends or family. “You can refine the AI’s suggestions by giving feedback, helping it become more accurate in offering thoughtful, tailored gift ideas,” Licato said in a . Recent suggests that many online shoppers are already asking AI to help them pick products. AI referrals to retail sites have increased eightfold since 2023; the software firm expects the trend to pick up even more this holiday season. In fact, a from Debt.com found that 65% of shoppers said they were willing to spend more than usual on a gift if AI gave them an ideal recommendation. By now, most folks are accustomed to using Google to do basic product research, probably by pecking in “best” followed by whatever type of product they’re searching for. In milliseconds, Google populates pages and pages of results, usually topped by several sponsored products. But AI works a little differently. And not all AI chatbots are created equally. Licato recommends using reputable ones like ChatGPT and Claude, which use advanced language-learning models that are trained with extensive amounts of data and have real-time access to the internet. Many retailers now have their own on-site AI chatbots. Take Amazon’s shopping-assistant chatbot, Rufus, for example. Rufus can help you search for products... but only ones on Amazon.com. In some cases, these retailer-run AI tools might not be as advanced as ChatGPT, or they may have different goals such as only selling you products offered on the site. When you’ve decided on which AI tool you want to use, tell it a little bit about your shopping goals and budget. According to RetailWire’s , one major perk of using a tool like ChatGPT over a regular search engine is that AI uses natural language, not just a few key words. You can describe at length what you’re looking for — even if you don’t exactly know what that is yet. You can also feed the chatbot as much information about the person you’re shopping for as you want. Basic facts like their interests, relation to you, hobbies and more can go a long way in getting tailored gift ideas (though Licato suggests using only publicly available information on the person if you have privacy concerns). After you’ve homed in on the item you want, you can get even more specific recommendations. The chatbot can also help you compare prices across retailers if it’s hooked up to live search engines. Just make sure the pricing is accurate. Licato recommends asking the chatbot to provide links directly to the site so you can double check. Once you get the perfect gift, all that’s left is deciding whether to tell the recipient that ChatGPT came up with the idea. Includes VPN & password manager 250X Faster Fraud Alerts than Competitors* Up to $5 Million in Identity Theft Insurance AI Spam Call & Message Protection 3-Bureau Credit Monitoring & Credit Lock Service Monthly Credit Score1 & Annual Credit Reports Up to $3 million identity theft coverage 1 1 Comprehensive 3-bureau monitoring system All Plans Include $1 Million Identity Theft Insurance* Real Time Monitoring of Your SSN, Accounts & Identity 3-Bureau Credit Monitoring & Monthly Credit Score1 Online and Device Security Over 40 years of experience in the field $1 million identity theft insurance & recovery 3 bureau credit monitoring Bank and credit card activity alerts VPN through mobile app Adam Hardy is Money's lead data journalist. He writes news and feature stories aimed at helping everyday people manage their finances. He joined Money full-time in 2021 but has covered personal finance and economic topics since 2018. Previously, he worked for Forbes Advisor, The Penny Hoarder and Creative Loafing.In addition to those outlets, Adam’s work has been featured in a variety of local, national and international publications, including the Asia Times, Business Insider, Las Vegas Review-Journal, Yahoo! Finance, Nasdaq and several others. Adam graduated with a bachelor’s degree from the University of South Florida, where he studied magazine journalism and sociology. As a first-generation college graduate from a low-income, single-parent household, Adam understands firsthand the financial barriers that plague low-income Americans. His reporting aims to illuminate these issues.Since joining Money, Adam has already written over 300 articles, including a cover story on financial surveillance, a profile of Director Rohit Chopra of the Consumer Financial Protection Bureau and an investigation into flexible spending accounts, which found that workers forfeit billions of dollars annually through the workplace plans. He has also led data analysis on some of Money’s marquee rankings, including Best Places to Live, Best Places to Travel and Best Hospitals. He regularly contributes data reporting for Best Colleges, Best Banks and other lists as well.Adam also holds a multimedia storytelling certificate from Poynter’s News University and a data journalism certificate from the Investigative Reporters and Editors (IRE) at the University of Missouri.In 2017, he received an English teaching certification from the University of Cambridge, which he utilized during his time in Seoul, South Korea. There, he taught students of all ages, from 5 to 65, and worked with North Korean refugees who were resettling in the area.Now, Adam lives in Saint Petersburg, Florida, with his pup Bambi. He is a card-carrying shuffleboard club member.
NoneWASHINGTON (AP) — President Joe Biden had long pledged that he would not pardon his son, Hunter, who was set to be sentenced this month for gun and tax convictions. But on Sunday, the president did it anyway. The sweeping pardon covers not only Hunter Biden's convictions in two cases in Delaware and California, but also any other “offenses against the United States which he has committed or may have committed or taken part in during the period from January 1, 2014 through December 1, 2024.” Biden is hardly the first president to deploy his pardon powers to benefit those close to him. But it was still a surprising reversal for a man who pledged to restore norms and respect for the rule of law. The U.S. Constitution says that a president has the power to grant clemency, which includes both pardons and commutations. A pardon forgives federal criminal offenses; a commutation reduces penalties but isn't as sweeping. The power has its roots in English law — the king could grant mercy to anyone — and it made it over the ocean to the American colonies and stuck around. The U.S. Supreme Court has found the presidential pardon authority to be very broad. And presidents use the power a lot: Donald Trump granted 237 acts of clemency during his four years in office and Barack Obama granted clemency 1,927 times in his eight years. Presidents have forgiven drug offenses, fraud convictions and Vietnam-era draft dodgers, among many other things. But a president can only grant pardons for federal offenses, not state ones. Impeachment convictions also aren't pardonable. Hunter Biden was convicted in June of lying on a federal form when he purchased a gun in 2018 and swore that he wasn’t a drug user. Just months later, he pleaded guilty to charges accusing him of a scheme to avoid paying at least $1.4 million in taxes. Prosecutors alleged he lived lavishly while flouting the tax law, spending his cash on things like strippers and luxury hotels — “in short, everything but his taxes.” Both cases stemmed from a period in Hunter Biden’s life in which he struggled with drug and alcohol abuse before becoming sober in 2019. After the gun trial aired salacious and unflattering details about Hunter Biden’s life, the president’s son said he agreed to plead guilty to the tax charges to spare his family another embarrassing criminal trial. The tax trial was also expected to showcase details about Hunter Biden’s foreign business dealings, which Republicans have seized on to try to paint the Biden family as corrupt. Hunter Biden was supposed to be sentenced this month in the two cases by judges in California and Delaware who were nominated to the bench by Trump. Special counsel David Weiss’ office had not said whether prosecutors had planned to seek prison time. The tax charges carried up to 17 years behind bars and the gun charges were punishable by up to 25 years in prison, though federal sentencing guidelines were expected to call for far less time and it was possible the younger Biden would have avoided prison time entirely. Biden’s legal team filed Sunday night in both Los Angeles and Delaware asking the judges handling his gun and tax cases to immediately dismiss them, citing the pardon. But Weiss' team is opposing the dismissal of the cases, arguing the dockets should merely be marked "closed." Prosecutors also strongly pushed back on the claim that the cases were tainted by politics. "The Government does not challenge that the defendant has been the recipient of an act of mercy," prosecutors wrote in court papers. But they added: "That does not mean the grand jury’s decision to charge him, based on a finding of probable cause, should be wiped away as if it never occurred. It also does not mean that his charges should be wiped away because the defendant falsely claimed that the charges were the result of some improper motive or selective prosecution.” Yes. Hunter Biden has been under federal investigation since 2020. He reached a deal with federal prosecutors and was supposed to plead guilty last year to misdemeanor tax offenses and would have avoided prosecution in the gun case as long he stayed out of trouble for two years. But the plea hearing quickly unraveled when the judge raised concerns about unusual aspects of the deal. He was subsequently indicted in the two cases, and he’s claimed that he was singled out because he is the president’s son. The president told reporters earlier this summer that he would not pardon his son. “I’m extremely proud of my son Hunter. He has overcome an addiction. He is one of the brightest, most decent men I know,” he said. “I abide by the jury decision. I will do that and I will not pardon him.” White House press secretary Karine Jean-Pierre said as recently as Nov. 8 that Biden would not pardon his son. In his statement Sunday, Biden said that his son had been “selectively, and unfairly, prosecuted.” Biden has been concerned — as Hunter Biden was — about his political adversaries. Also, the president is no longer running for office. He made his no-pardon pledge before he dropped out of the presidential race in June. In his statement, the president said it was clear that his son was treated differently from other defendants in similar predicaments. The plea deal unraveled and Biden’s political opponents took credit for pressuring the process, he said. “No reasonable person who looks at the facts of Hunter’s cases can reach any other conclusion than Hunter was singled out only because he is my son — and that is wrong. There has been an effort to break Hunter — who has been five and a half years sober, even in the face of unrelenting attacks and selective prosecution. In trying to break Hunter, they’ve tried to break me — and there’s no reason to believe it will stop here. Enough is enough.” Yes. In his final weeks in office, Trump pardoned Charles Kushner, the father of his son-in law, Jared Kushner. He also pardoned multiple allies convicted in special counsel Robert Mueller’s Russia investigation. Trump over the weekend announced plans to nominate the elder Kushner to be the U.S. envoy to France in his next administration. President Bill Clinton pardoned his half-brother Roger Clinton in 2001, after he had completed a prison term for drug charges. Clinton also pardoned his former business partner Susan McDougal, who had been sentenced to two years in prison for her role in the Whitewater real estate deal.
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Dry AMD Market Size in the 7MM was ~ USD 1,300 million in 2023, estimated DelveInsight 11-25-2024 11:14 PM CET | Health & Medicine Press release from: ABNewswire DelveInsight's "Dry AMD Market Insights, Epidemiology, and Market Forecast-2034" report delivers an in-depth understanding of the Dry AMD, historical and forecasted epidemiology as well as the Dry AMD market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. Discover Key Insights into the Dry AMD Market with DelveInsight's In-Depth Report @ Dry AMD Market Size [ https://www.delveinsight.com/sample-request/dry-age-macular-degeneration-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Key Takeaways from the Dry AMD Market Report * In November 2024:- Stealth BioTherapeutics Inc.- A Phase 3, Double-Masked, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects Who Have Dry Age-Related Macular Degeneration (Dry AMD). * In November 2024:- Cognition Therapeutics- This is a Phase 2, prospective, multicenter, randomized, double-masked, placebo-controlled 104-week study to assess the efficacy, safety, and tolerability of orally delivered CT1812 compared to placebo in participants with GA associated with dry AMD. * The total prevalent cases of AMD in the 7MM was nearly 68,347,900 in 2023. * Among the 7MM, the US accounted for the highest prevalent cases of dry AMD in 2023, with around 20,970,000 cases; these cases are expected to increase during the forecast period. * Several researchers reported a declining prevalence of late AMD in the United States when comparing data from the 2000s with data gathered in previous decades. * In 2023, the geographical atrophy accounted for nearly 955,900 cases in EU4 and the UK. * According to the estimates, in Japan, it is observed that age-specific cases of geographic atrophy were most prevalent in the 85+ years age group, accounting for over 40% of total cases in 2023. * The leading Dry Age-Related Macular Degeneration Companies such as Alkeus Pharmaceuticals, Novartis, Molecular Partners, Stealth BioTherapeutics, Regenerative Patch Technologies, Aevitas Therapeutics, NGM Biopharmaceuticals, InflammX Therapeutics, Lineage Cell Therapeutics, Alexion AstraZeneca Rare Disease, Belite Bio, Katairo, Cognition Therapeutics, Apellis Pharmaceuticals, Galimedix Therapeutics, Amarna Therapeutics, 4D Molecular Therapeutics, Aviceda Therapeutics, Isarna Therapeutics , and others. * Promising Dry Age-Related Macular Degeneration Therapies such as Iptacopan (LNP023), ALK-001, RPESC-RPE-4W, PRIMA, QA102, Active Comparator CT1812, ASP7317, Tacrolimus, OCU410, GT005, AVD-104 , and others. Stay ahead in the Dry AMD Therapeutics Market with DelveInsight's Strategic Report @ Dry AMD Market Outlook [ https://www.delveinsight.com/sample-request/dry-age-macular-degeneration-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Dry AMD Epidemiology Segmentation in the 7MM * total prevalent cases of AMD, * stage-specific prevalent cases of AMD, * total prevalent cases of geographic atrophy, * total prevalent cases of dry AMD, * total diagnosed prevalent cases of dry AMD, * age-specific cases of early and intermediate AMD, * age-specific cases of geographic atrophy, * geographic atrophy cases by visual impairment Download the report to understand which factors are driving Dry AMD epidemiology trends @ Dry AMD Prevalence [ https://www.delveinsight.com/sample-request/dry-age-macular-degeneration-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Marketed Dry Age-related Macular Degeneration Drugs IZERVAY (avacincaptad pegol): Astellas Pharma/Iveric Bio IZERVAY, also known as avacincaptad pegol is designed to target and inhibit complement factor C5. Complement factor C5 is a central component of the complement cascade and is believed to be involved in the development and progression of dry AMD. IZERVAY binds to C5 and inhibits its cleavage into the terminal fragments C5a and C5b. By inhibiting the formation of complement system terminal fragments, IZERVAY may decrease the activation of inflammasomes and the formation of membrane attack complexes (MAC), which occur at the end of the complement cascade. In August 2023, the US FDA approved IZERVAY for the treatment of geographic atrophy secondary to AMD. Concurrently, Astellas Pharma announced that the European Medicines Agency (EMA) has accepted Iveric Bio's MAA for avacincaptad pegol for the treatment of geographic atrophy secondary to AMD. SYFOVRE (pegcetacoplan): Apellis Pharmaceuticals SYFOVRE is a targeted C3 inhibitor designed to regulate excessive complement activation, which can lead to the onset and progression of many serious diseases. Pegcetacoplan is a type of synthetic cyclic peptide conjugated to a polyethylene glycol polymer that binds specifically to C3 and C3b. The company is evaluating pegcetacoplan in several clinical studies, including paroxysmal nocturnal hemoglobinuria (PNH), geographic atrophy (GA), cold agglutinin disease (CAD), warm antibody autoimmune hemolytic anemia (wAIHA), complement-dependent nephropathies (CDN). SYFOVRE is the first and only approved therapy for geographic atrophy secondary to AMD. In January 2024, the CHMP of the EMA adopted a negative opinion on the MAA of intravitreal pegcetacoplan for the treatment of geographic atrophy secondary to AMD. Emerging Dry Age-related Macular Degeneration Drugs * Iptacopan (LNP023): Novartis Novartis Pharmaceuticals is developing Iptacopan, an oral small-molecule inhibitor of complement factor B (FB) with potential immunomodulatory activity. Upon administration, FB inhibitor LNP023 binds to FB and prevents the formation of the alternative pathway (AP) C3-convertase (C3bBb). This limits the cleavage of C3 to the active fragment C3b and may prevent C3b-mediated extravascular hemolysis in certain complement-driven disorders such as intermediate age-related macular degeneration (iAMD), C3 glomerulopathy (C3G), paroxysmal nocturnal hemoglobinuria (PNH), etc. Recently, in December 2023, the US FDA approved FABHALTA (ipatocan) as the first oral monotherapy for adults with paroxysmal nocturnal hemoglobinuria (PNH) (Novartis, 2023). Currently, the company is investigating iptacopan in the Phase II trial (NCT05230537) for the treatment of patients with early and intermediate age-related macular degeneration. * ALK-001: Alkeus Pharmaceuticals Allegro Ophthalmics is developing risuteganib (also known as ALG-1001), a breakthrough integrin-regulating therapy for ocular health that reduces mitochondrial dysfunction involved in intermediate dry AMD. By targeting multiple pathways, risuteganib helps reduce the cellular burden of oxidative stress and restores retinal homeostasis. Research suggests that risuteganib interferes with integrin functions that have been implicated in retinal diseases, giving it the potential for a broad-spectrum effect on different pathways of oxidative stress. Currently, the company has received the US FDA agreement under Special Protocol Assessment (SPA) for Phase IIb/III clinical trial of risuteganib for the treatment of intermediate, non-exudative age-related macular degeneration (dry AMD). Moreover, the overall protocol design of Phase IIb/III dry AMD clinical trial was finalized by the US FDA. Get In-Depth Knowledge on Dry AMD Market Trends and Forecasts with DelveInsight @ Dry AMD Treatment Market [ https://www.delveinsight.com/sample-request/dry-age-macular-degeneration-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Dry AMD Market Outlook Geographic atrophy, the advanced stage of dry AMD, has emerged as a prominent focus of research. Current investigations predominantly center on therapies targeting complement inhibitors of C3 and C5, pivotal factors in triggering inflammation and subsequent cell death within the eye. Extensive studies led by the National Eye Institute and esteemed researchers globally have unveiled the likelihood of an overactive complement system as a central player in the genesis of dry AMD and its evolution toward GA. Enhancing comprehension of the pathophysiology of geographic atrophy resulting from dry AMD can benefit patients, optometrists, and ophthalmologists alike. This improved understanding could lead to more accurate identification and diagnosis of patients, potentially lessening the burden of the disease and extending their visual function over time. Dry AMD Drugs Market Integrin inhibitor have been effective in several preclinical models, and promising results have been reported thus far from clinical trials. Indeed, most of the current avSs3 clinical investigations centre on treating eye diseases (age-related macular degeneration (AMD) using topically dosed or intravitreally injected small molecules and peptides, although these molecules also inhibit other av integrins and/or a5Ss1 to varying degrees. The molecules that have progressed the furthest in the clinic are risuteganib (Luminate, Allegro Ophthalmics). It is a small peptide integrin regulator protecting cells of the human RPE against dysfunction related to oxidative stress. With age, decreased mitochondrial oxidative phosphorylation increases the generation of reactive oxygen species and decreased metabolic activity, thus negatively affecting cellular bioenergetics and mitochondrial functioning. It is also known that RPE mitochondrial dysfunction contributes to the oxidative stress causing AMD. Unlock Strategic Insights with DelveInsight's Comprehensive Dry AMD Market Report @ Dry AMD Market Drivers and Barriers [ https://www.delveinsight.com/sample-request/dry-age-macular-degeneration-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Scope of the Dry AMD Market Report * Coverage- 7MM * Dry AMD Companies- Alkeus Pharmaceuticals, Novartis, Molecular Partners, Stealth BioTherapeutics, Regenerative Patch Technologies, Aevitas Therapeutics, NGM Biopharmaceuticals, InflammX Therapeutics, Lineage Cell Therapeutics, Alexion AstraZeneca Rare Disease, Belite Bio, Katairo, Cognition Therapeutics, Apellis Pharmaceuticals, Galimedix Therapeutics, Amarna Therapeutics, 4D Molecular Therapeutics, Aviceda Therapeutics, Isarna Therapeutics, and others. * Dry Age-Related Macular Degeneration Therapies- Iptacopan (LNP023), ALK-001, RPESC-RPE-4W, PRIMA, QA102, Active Comparator CT1812, ASP7317, Tacrolimus, OCU410, GT005, AVD-104, and others. * Dry AMD Therapeutic Assessment: Dry AMD Current marketed and Lipodystrophy Emerging Therapies * Dry AMD Market Dynamics: Dry AMD Market drivers and Dry AMD Market Barriers Table of Content 1. Key Insights 2. Executive Summary 3. Dry Age-Related Macular Degeneration Competitive Intelligence Analysis 4. Dry Age-Related Macular Degeneration Market Overview at a Glance 5. Dry Age-Related Macular Degeneration Disease Background and Overview 6. Dry Age-Related Macular Degeneration Patient Journey 7. Dry Age-Related Macular Degeneration Epidemiology and Patient Population 8. Dry Age-Related Macular Degeneration Treatment Algorithm, Current Treatment, and Medical Practices 9. Dry Age-Related Macular Degeneration Unmet Needs 10. Key Endpoints of Dry Age-Related Macular Degeneration Treatment 11. Dry Age-Related Macular Degeneration Marketed Products 12. Dry Age-Related Macular Degeneration Emerging Therapies 13. Dry Age-Related Macular Degeneration Seven Major Market Analysis 14. Attribute Analysis 15. Dry Age-Related Macular Degeneration Market Outlook (7 major markets) 16. Dry Age-Related Macular Degeneration Access and Reimbursement Overview 17. KOL Views on the Dry Age-Related Macular Degeneration Market 18. Dry Age-Related Macular Degeneration Market Drivers 19. Dry Age-Related Macular Degeneration Market Barriers 20. Appendix 21. DelveInsight Capabilities About Us DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve. Media Contact Company Name: DelveInsight Business Research LLP Contact Person: Yash Bhardwaj Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=dry-amd-market-size-in-the-7mm-was-usd-1300-million-in-2023-estimated-delveinsight ] Phone: 09650213330 Address:304 S. Jones Blvd #2432 City: Las Vegas State: NV Country: United States Website: https://www.delveinsight.com/case-study/in-licensing-opportunity This release was published on openPR.
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